Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, molecular formula is C2H3F3N2O, belongs to pyridazines compound. In a document, author is Ahmed, Marwa F., introduce the new discover, Safety of 2,2,2-Trifluoroacetohydrazide.
Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies
Novel hybrids of pyridazine-pyrazoline were synthesized aiming to develop new antiproliferative candidates. All compounds were submitted to the National Cancer Institute (NCI), USA, and many were proved to have significant antiproliferative activity. In addition, in vitro studies of the epidermal growth factor receptor (EGFR) inhibition showed that compounds IXn, IXg, IXb and IXI exhibited excellent inhibitory effect (IC50 = 0.65, 0.75, 0.82 and 0.84 mu M, respectively) compared to Erlotinib (IC50 = 0.95 mu M). The mechanistic effectiveness in cell cycle progression, apoptotic induction and gene regulation were assessed for the promising compounds IXg and IXn due to their significant EGFR inhibition. Flow cytometeric analysis indicated that compounds IXg and IXn result in increased cell numbers in phase G2/M, suggesting cell cycle arrest in phase G2/M in UO-31cells. Furthermore, real time PCR assay illustrated that compounds IXg and IXn elevated Bax/Bcl2 ratio which confirmed the mechanistic pathway of them. Moreover, the apoptotic induction of UO-31 renal cancer cells was enhanced effectively through activation of caspase-3 by compounds IXg and IXn. On the other hand, molecular docking study was performed to investigate binding mode of interaction of compounds with EGFR-PK in the active site with the aim of rationalizing its promising inhibitory activity. Finally, based on the aforementioned findings, compounds IXg and IXn could be considered as effective apoptosis modulators and promising leads for future development of new anti-renal cancer agents.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 1538-08-5. Safety of 2,2,2-Trifluoroacetohydrazide.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem