Application of 103-85-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 103-85-5, Name is 1-Phenylthiourea, SMILES is S=C(N)NC1=CC=CC=C1, belongs to pyridazines compound. In a article, author is Josefa, Paat-Estrella, introduce new discover of the category.
Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools
The aim of this study was to synthesize a new oxetan-phenyltetrahydropyridazine-3,6-dione derivative (compound 6) using different techniques. The first method was achieved by the preparation of a phenylhydrazine derivative (2) using three-components system (3,17-aldol-estradiol, phenylhydrazine, 5-hexyn-3-ol) in the presence of Copper(II). Then, 2 was reacted with tert-butyldimethylsilyl chloride to form the compound 3 (trimethylbutan-silyloxy-steroid-hydrazine). Following, a pyridazine derivative (4) was prepared by the reaction of 3 with succinic acid using boric as catalyst. The compound 4 was reacted with hydrofluoric acid to form the tetrahydropyridazine-3,6-dione (5). Finally, the preparation of 6 was carried out by the reaction of 5 with CopperII. Spectroscopy analyses NMR was used to confirm the chemical structure of compounds. In conclusion, a facile method to synthesize an oxetan-phenyltetrahydropyridazine-3,6-dione is reported.
Application of 103-85-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 103-85-5.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem