Chemistry is an experimental science, Computed Properties of C4F10O2S, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 375-72-4, Name is 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-sulfonyl fluoride, molecular formula is C4F10O2S, belongs to pyridazines compound. In a document, author is Xiang, Hao-Yue.
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors
A library of new 2-substituted pyrrolo[1,2-b]pyridazine derivatives were rapidly assembled and identified as PARP inhibitors. Structure-activity relationship for this class of inhibitor resulted in the discovery of most potent compounds 15a and 15b that exhibited about 29- and 5- fold selective activity against PARP-1 over PARP-2 respectively. The antiproliferative activity of the as-prepared compounds were demonstrated by further celluar assay in BRCA2-deficient V-C8 and BRCA1-deficient MDA-MB-436 cell lines, displaying that compound 15b could robustly reduce the corresponding cell proliferation and growth with CC(50)s of 340 and 106 nM respectively. The PK property of 15b was also investigated here.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 375-72-4, in my other articles. Computed Properties of C4F10O2S.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem