Chemistry, like all the natural sciences, Formula: C7H6F3N, begins with the direct observation of nature¡ª in this case, of matter.88-17-5, Name is 2-(Trifluoromethyl)aniline, SMILES is NC1=CC=CC=C1C(F)(F)F, belongs to pyridazines compound. In a document, author is Feraldi-Xypolia, Alexandra, introduce the new discover.
Synthesis of -(Trifluoromethyl)pyridazine Derivatives
Over the last decades, an increasing interest in -(trifluoromethyl)pyridazines in medicinal chemistry has been noticed. This interest stems firstly from the recent development of biologically active pyridazines as well as from the capacity of the pyridazine ring to be a bioisoster of other heterocycles. Secondly, due to the influence of a fluorine atom on the chemical and physico-chemical properties of organic compounds, fluorinated pyridazines have been an attractive scaffold for medicinal chemists. Consequently, the methods that allow the synthesis of fluorinated pyridazines, and more specifically pyridazines possessing either one or two CF3 groups to the nitrogen atoms, are of great interest and are reported in this review.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 88-17-5. Formula: C7H6F3N.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem