With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.
To a 250-mL round-bottom flask was placed a solution of 6- chloro-2,3-dihydropyridazin-3-one (1.87 g, 14.33 mmol) and 2-chloro-N-[4- (trifluoromethyl)phenyl]propanamide (3 g, 11.92 mmol, as prepared in the previous step) in acetone (60 mL) then K2CO3 (4.9 g, 35.20 mmol) was added. The reaction was stirred at 60C for 16 h, then the solids were filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography eluting with EtO Ac/petroleum ether (1:20 up to 1: 1) affording 1.4 g (34%) of the title compound as a white solid. Mass Spectrum (LCMS, ESI pos): Calcd. for (0182) Ci4H12ClF3N302+: 346.1 (M+H); Found: 346.1. H NMR (300 MHz, DMSO-cfe): delta 10.62 (s, 1H), 7.80-7.77 (d, / = 8.4 Hz, 2H), 7.70-7.62 (m, 3H), 7.12-7.08 (d, / = 9.9 Hz, 1H), 5.43-5.34 (q, / = 7.2 Hz, 1H), 1.61-1.59 (d, / = 7.2 Hz, 3H)., 19064-67-6
19064-67-6 6-Chloro-3-hydroxypyridazine 252828, apyridazine compound, is more and more widely used in various.
Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; PARKS, Daniel; MUNOZ, Benito; (66 pag.)WO2018/81378; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem