With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.823-58-5,4-Amino-3,6-dichloropyridazine,as a common compound, the synthetic route is as follows.
823-58-5, To a stirred suspension of 3,6-dichloropyridazin-4-amine (Step 112.1) (1.49 g, 9.09 mmol) in EtOH (15 mL) was added hydrazine hydrate (11.04 mL, 227 mmol) and the resulting mixture was heated up and stirred at 100 00 for 3 hr. The reaction was cooled down to RT andconcentrated under reduced pressure. The crude product was triturated with water (25 mL) to afford the title product (478 mg, 3 mmol, 33% yield) as yellow solid. tR: 0.24 mm (LC-MS 2); ESIMS: 160 [M+H] (LC-MS 2); ESl-MS: 158 [M-H] (LC-MS 2).
The synthetic route of 823-58-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191896; (2014); A1;,
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