Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Aggarwal, Ranjana, once mentioned the application of 39825-33-7, Name is H-Ala-OiPr, molecular formula is C6H13NO2, molecular weight is 131.17, MDL number is MFCD12796134, category is pyridazines. Now introduce a scientific discovery about this category, Name: H-Ala-OiPr.
An expeditious one-pot multicomponent synthesis of sterically hindered bis-1,2,4-triazolopyridazines under solvent-free conditions
A simple and ecologically facile synthesis of sterically hindered 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b:3′,4′-f]pyridazines was accomplished via a three-component reaction sequence between 3,6-dihydrazinopyridazine, an aromatic or heteroaromatic aldehyde and iodobenzene diacetate (IBD) on grinding at room temperature. The 3,6-bis-arylidenehydrazinopyridazine intermediates, generated in situ, undergo oxidative cyclization to afford the title compounds. The present protocol has excellent yields, short reaction times, broad substrate scope, is a solvent-free greener synthesis, and has an easy purification of product. [GRAPHICS] .
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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem