5469-69-2,5469-69-2, 3-Amino-6-chloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A suspension of 6-chloropyridazin-3 -amine (7.35 g, 56.7 mmol) in hydroiodic acid 57 % in water (102 g, 59.9 ml, 454 mmol) was heated to 100C under an argon atmosphere and stirring at that temperature was continued overnight. The dark reddish brown suspension was cooled to r.t. and EtOAc (5 ml) was added. The suspension was stirred vigourously for 5 min. The solid was then collected by filtration, washed with EtOAc and dried. The light yellow collected crystals were taken up in MeOH (120 ml), and sodium hydroxide (2.5 g, 62.4 mmol) was added to the suspension which was heated to reflux and stirred for 5 min, turning to an almost clear yellow solution. The mixture was cooled to r.t. and concentrated. The residue was triturated in 45 ml H20. The suspension was stirred at r.t. for 15 min. The product was collected by filtration, washed with H20 and dried to provide the title compound (10.9 g, 87%) as off-white solid. MS: M = 222.1 (M+H)+
5469-69-2 3-Amino-6-chloropyridazine 21643, apyridazine compound, is more and more widely used in various.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; LERNER, Christian; WO2013/178569; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem