With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174607-36-4,6-(Trifluoromethyl)pyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
Description 87; 3-Chloro-6-trifluoromethvlpvridazine; A mixture of Description 86 (2.00 g, 12.2 mmol) and phosphorous oxychloride (11.4 ml, 122 mmol) was heated at 90C for 6 hours. The excess phosphorous oxychloride was removed by evaporation, and the residue then dissolved in dichloromethane (100 ml) and ice (100 g) added. The mixture was stirred for 30 min, then carefully basified by the addition of saturated aqueous K2CO3, filtered and evaporated to give the title compound as a pale brown solid (2 g, 89%). IH NMR (400 MHz, CDCl3) 7.79 (1 H, d, J9.0), 7.86 (1 H, d, J9.0).
As the paragraph descriping shows that 174607-36-4 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2005/47279; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem