932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, belongs to pyridazine compound, is a common compound. SDS of cas: 932-22-9In an article, once mentioned the new application about 932-22-9.
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors
A pyridazin-4-one fragment 4 (hCatS IC50 = 170 muM) discovered through Tethering was modeled into cathepsin S and predicted to overlap in S2 with the tetrahydropyridinepyrazole core of a previously disclosed series of CatS inhibitors. This fragment served as a template to design pyridazin-3-one 12 (hCatS IC50 = 430 nM), which also incorporates P3 and P5 binding elements. A crystal structure of 12 bound to Cys25Ser CatS led to the synthesis of the potent diazinone isomers 22 (hCatS IC50 = 60 nM) and 27 (hCatS IC50 = 40 nM).
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2287 – PubChem