One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 6-Chloropyridazine-3-carboxylic acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5096-73-1, Name is 6-Chloropyridazine-3-carboxylic acid, molecular formula is C5H3ClN2O2
Coordination Assisted Distal C?H Alkylation of Fused Heterocycles
Distal C?H bond functionalization of heterocycles remained extremely challenging with covalently attached directing groups (DG). Lack of proper site for DG attachment and inherent catalyst poisoning by heterocycles demand alternate routes for site selective functionalization of their distal C?H bonds. Utilizing non-productive coordinating property to hold the heterocycle into the cavity of a template system in a host?guest manner, we report distal C?H alkylation (C-5 of quinoline and thiazole, C-7 of benzothiazole and benzoxazole) of heterocycles. Upon complexation with heterocyclic substrate, nitrile DG in template directs the metal catalyst towards close vicinity of the specific distal C?H bond of the heterocycles. Our hypothesized pathway has been supported by various X-ray crystallographically characterized intermediates.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 6-Chloropyridazine-3-carboxylic acid, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5096-73-1, in my other articles.
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2062 – PubChem