With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37444-46-5,Pyridazin-3-ylmethanol,as a common compound, the synthetic route is as follows.
[00284] Thionyl chloride (3.05 ml, 42 mmol) was added to an ice-cooled flask containing the title compound of Preparation 26 (920 mg, 8 mmol) and the reaction mixture stirred for 45 minutes at room temperature, then evaporated under reduced pressure. The residue was azeotroped with toluene (40 ml) to furnish the crude title compound (1.4 g) as a brown solid, which was of sufficient purity for generating the free base required for use in subsequent alkylation reactions. delta (DMSOd6): 4.98 (2H, s), 7.80 (1H, m), 7.90 (1H, d), 8.19 (1H, s), 9.22 (1H, d).
37444-46-5, The synthetic route of 37444-46-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Pfizer Inc.; US6723719; (2004); B1;,
Pyridazine – Wikipedia
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