1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of tert-butyl N-[(lR,5S,8s)-3-azabicyclo[3.2.1]octan-8-yl]carbamate (700 mg, 3.09 mmol), 3,5-dichloropyridazine (691 mg, 4.64 mmol) in ethanol (42 mL) with triethylamine (1.25 g, 12.4 mmol) was stirred for 3 h at 85 C and then 60 h at RT. The reaction mixture was diluted with 30 mL H20 and extracted with EtOAc (3 x 30 mL). The organic layers were dried over MgS04 and concentrated in vacuum. The crude material was purified by flash chromatography (silica gel 20 g, eluent 0 % to 70 % EtOAc in heptane) to afford tert-butyl N- [(lR,5S,8s)-3-(6-chloropyridazin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl]carbamate 923 mg, 88 %. MS ES+ (m/z): 339.2 [(M+H)+].
As the paragraph descriping shows that 1837-55-4 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BAUMANN, Karlheinz; GALLEY, Guido; JAESCHKE, Georg; JAKOB-ROETNE, Roland; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; RODRIGUEZ-SARMIENTO, Rosa Maria; (178 pag.)WO2017/97728; (2017); A1;,
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