867130-58-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.867130-58-3,6-Oxo-1,6-dihydropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
[0373] A solution of 6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid (11.5 g), TBTU (25.3 g), triethylamine (20.9 mL) and 40 mL DMF in 200 mL THF was stirred for 30 minutes at ambient temperature. Then n-butyl (S)-3-amino-tetrahydrofuran-3-carboxylate (14.0 g) was added and the mixture was stirred further overnight. For working up the mixture was evaporated to dryness in vacuo and the residue was stirred with 200 mL of ethyl acetate. This solution was washed twice with 5% sodium hydrogen carbonate solution, then dried and evaporated down. The product was thus obtained in a yield of 90% of theory. [0374] C14H19N3O5 (309.3) [0375] Thin layer chromatogram (silica gel; dichloromethane/ethanol 19:1): Rf=0.16
The synthetic route of 867130-58-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hauel, Norbert; Kuelzer, Raimund; US2014/38977; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem