With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.289-80-5,Pyridazine,as a common compound, the synthetic route is as follows.
General procedure: To a solution of the corresponding [1,2,3]triazolo[1,5-a]pyridine 1 in anhydrous toluene at -40 C under an argon current, a solution of 1.6 n-BuLi in hexane (1.1 equiv) was added with stirring; a deep red color developed. The mixture was kept at -40 C for 4 h. The azine (1.1equiv) in dry toluene solution was added and the mixture was kept inthe cold bath at -40 C for 2 h. The solution was treated with a saturateds olution of NH4Cl followed by aq KMnO4 solution for 30 min at r.t. The mixture was filtered over Celite, the organic and aqueous layers were separated, the aqueous layer was extracted with CH2Cl2, the combined organic extracts were dried (Na2SO4), and the solution was filtered and concentrated to give the crude product., 289-80-5
As the paragraph descriping shows that 289-80-5 is playing an increasingly important role.
Reference£º
Article; Adam, Rosa; Abarca, Belen; Ballesteros, Rafael; Synthesis; vol. 49; 22; (2017); p. 5059 – 5066;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem