34127-22-5, Name is Ethyl 3,6-dichloropyridazine-4-carboxylate, belongs to pyridazine compound, is a common compound. name: Ethyl 3,6-dichloropyridazine-4-carboxylateIn an article, once mentioned the new application about 34127-22-5.
Triazolopyridazine LRRK2 kinase inhibitors
Leucine-rich repeat kinase 2 (LRRK2) has been implicated in the pathogenesis of Parkinson’s disease (PD). Inhibition of LRRK2 kinase activity is a therapeutic approach that may lead to new treatments for PD. Herein we report the discovery of a series of [1,2,4]triazolo[4,3-b]pyridazines that are potent against both wild-type and mutant LRRK2 kinase activity in biochemical assays and show an unprecedented selectivity towards the G2019S mutant. A structural rational for the observed selectivity is proposed.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2958 – PubChem