5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 4,5-dibromo-2,3-dihydropyridazin-3-one (90.4 mg, 0.36 mmol, 1.2 equiv.) in DMA(2 mL, 21.51 mmol) were added 3-[(2-methylphenyl)methyl]-3,6- diazabicyclo[3.1.1]heptane (60 mg, 0.30 mmol, 1 equiv.) and DIEA(76.7 mg, 0.59 mmol, 2 equiv.) at room temperature. The resulted mixture was stirred for 16 h at 100 degrees C. The reaction mixture was purified by Prep-HPLC with the following conditions (Column: XBridge Prep C18 OBD Column 19X150mm 5um; Mobile Phase A: Water(10 mmol/L NH4HCO3), Mobile Phase B: MeCN; Flow rate: 20 mL/min; Gradient: 35% B to 65% B in 9 min; 254 nm; Rt: 7.4 min) to afford 4-bromo-5-[3-[(2-methylphenyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-6- yl]-2,3-dihydropyridazin-3-one (5.1 mg, 4.58%) as a light yellow solid
The synthetic route of 5788-58-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GOLDFINCH BIO, INC.; YU, Maolin; DANIELS, Matthew, H.; HARMANGE, Jean-christophe, P.; TIBBITTS, Thomas, T.; LEDEBOER, Mark, W.; WALSH, Liron; MUNDEL, Peter, H.; MALOJCIC, Goran; (860 pag.)WO2019/55966; (2019); A2;,
Pyridazine – Wikipedia
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