1120-95-2, 3-Chloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1120-95-2
INTERMEDIATE 306,6-Dimethyl-2-[6-(pyrida2in-3-yloxy)-2,3-dihvdro-4H-l,4-benzoxazin-4-yl]-6,7- dihvdro[ 1 ,3]thiazolor5,4-clpyridin-4(5H)-oneA mixture of Intermediate 17 (53 mg, 0.16 mmol), cesium carbonate (105 mg,0.32 mmol) and 3,6-dichloropyridazine (24 mg, 0.16 mmol) in NMP (2 mL) was heated to 1100C for 12 h. After cooling to r.t. it was concentrated in vacuo. Purification by preparative etaPLC (Method 5) gave the title compound (15 mg, 23%) as an off-white solid. deltaeta (CDCl3) 8.94 (IH, dd, J4.5, 1.3 Hz), 8.02 (IH, d, J2.4 Hz), 7.49 (IH, dd, J8.9,4.5 Hz), 7.19 (IH, dd, J 8.9, 1.3 Hz), 6.89-7.03 (2H, m), 5.21 (IH, s), 4.31-4.39 (2H, m),4.09-4.18 (2H, m), 2.86 (2H, s), 1.37 (6H, s).
The synthetic route of 1120-95-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UCB PHARMA S.A.; WO2009/71895; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem