14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,14161-11-6
A mixture of 3,4,5-trichloropyridazine (0.5 g, 2.73 mmol), 4-(2,5- dimethoxyphenyl)piperidine hydrochloride (0.703 g, 2.73 mmol), and potassium carbonate (0.79 1 g, 5.72 mmol) in dioxane (10 ml) was heated to reflux for 1 h. Themixture was cooled and 35% hydrazine in water (2.469 ml, 27.3 mmol) was added and the mixture was heated to reflux for 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-5-(4-(2,5- dimethoxyphenyl)piperidin- 1 -yl)-3 -hydrazinylpyridazine as a brown oil. (M+H) =364.2.
The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
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