14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,14161-11-6
A mixture of 3,4,5-trichloro- pyridazine (200 mg, 0.0011 mol), intermediate 2 (see Example Al/b) (273 mg, 0.0011 mol) and diisopropylamine (0.38 ml, 0.0011 mol) was stirred in 2-propanol (4.0 ml) at 800C for 1 hour. The solvent was evaporated, and the crude mixture was taken back in EtOAc. The organic layer was washed with a saturated solution of sodium bicarbonate and with brine, dried (MgSO4), filtered, and the solvent was evaporated. The residue was purified by column chromatography over silica gel (40-63 mum) (eluent: EtOAc/cyclohexane 50/50). The pure fractions were collected and the solvent was evaporated, yielding 179 mg (41%) of intermediate 86 and intermediate 87 as a 1/1 mixture of two pyridazine compounds.
The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/32631; (2006); A1;,
Pyridazine – Wikipedia
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