With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1837-55-4,3,5-Dichloropyridazine,as a common compound, the synthetic route is as follows.,1837-55-4
(0606) [1,1 ‘-Bis(diphenylphosphino)ferrocene]dichloropalladium(II)dichloromethane (0.27 g, 0.33 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.39 g, 0.67 mmol) and Cs2C03( 13 g, 40.3 mmol) in dry toluene (65 mL) were heated at 40 C for 15 min while N2 was bubbling. Then, tert-butyl carbamate (3.1 g, 26.8 mmol) and 3,5- dichloropyridazine (CAS 1837-55-4, 2.5 g, 13.4 mmol) were added while N2 was bubbling. The mixture was stirred at 80C for 16 h. The mixture was diluted with H20 and extracted with EtOAc. The organic layer was separated, dried (MgS04), filtered and the solvents evaporated in vacuo. The crude product was purified by flash column chromatography (silica; EtOAc in heptane, from 0/100 to 50/50). The desired fractions were collected and the solvents evaporated in vacuo to yield intermediate 111 (1.4 g, 45%) and intermediate 112 (0.46 g, 15%) as white solids.
The synthetic route of 1837-55-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; DELGADO-JIMENEZ, Francisca; DE LUCAS OLIVARES, Ana Isabel; VEGA RAMIRO, Juan, Antonio; (224 pag.)WO2019/243531; (2019); A1;,
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