35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, belongs to pyridazine compound, is a common compound. Safety of 6-Chloropyridazine-3-carbonitrileIn an article, once mentioned the new application about 35857-89-7.
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core
With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer’s disease, we synthesized and evaluated a novel series of indole-benzoxazinones (Family I) and benzoxazine-arylpiperazine derivatives (Family II) for potential human acetylcholinesterase (hAChE) inhibitory properties. The most active compounds 7a and 7d demonstrated effective inhibitory profiles with Ki values of 20.3 ¡À 0.9 muM and 20.2 ¡À 0.9 muM, respectively. Kinetic inhibition assays showed non-competitive inhibition of AChE by the tested compounds. According to our docking studies, the most active compounds from both series (Families I and II) showed a binding mode similar to donepezil and interact with the same residues.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N948 – PubChem