Electric Literature of 63910-43-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.63910-43-0, Name is 4-Chloro-5-methoxypyridazin-3(2H)-one, molecular formula is C5H5ClN2O2. In a Article£¬once mentioned of 63910-43-0
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists
A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by alpha4beta1/VCAM-1 and alpha4beta 7MAdCAM-1 interactions. Concise syntheses were developed and applied for exploration of structure-activity relationships pertaining to the pyridazinone ring as well as the N-acyl phenylalanine scaffold. Potent dual antagonists of alpha4beta1 and alpha 4beta7 were generated from an amide subseries; antagonists selective for alpha4beta7 were identified from urea and carbamate-based subseries. The pharmacokinetic properties of selected members of the series have been determined in rats and demonstrate that the use of ester prodrugs and alterations to the amide linkage can lead to improved oral bioavailability in this series. An alpha4beta 7-selective member of the carbamate subseries (36c), upon oral admininstration, demonstrated in vivo efficacy in the mouse DSS colitis model.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 63910-43-0, and how the biochemistry of the body works.Electric Literature of 63910-43-0
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2188 – PubChem