27372-38-9, 6-Oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,27372-38-9
To a solution of 11 (568 mg, 4.00 mmol) in glacial acetic acid (2.0 mL) was vigorously stirred at slight boiling temperature, then bromine (230 muL, 4.50 mmol) was added via dropping funnel. When all of the bromine had been introduced, water (2.0 mL) was added and the reaction mixture was heated under reflux temperature overnight. After cooling to room temperature, the precipitate was filtrated, and then dried to give crude product 12 without further purification. The average yield of acid which precipitated was 334.1 mg (60.0%). Mp: 258.4-258.6 C (Ref. melting point 257 C [55]).
The synthetic route of 27372-38-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Qian, Hai-Yan; Wang, Zhi-Long; Xie, Xiao-Yu; Pan, You-Lu; Li, Gang-Jian; Xie, Xin; Chen, Jian-Zhong; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 598 – 611;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem