289-80-5,289-80-5, Pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The mixture of pyridazine (l -Im-8, l eq), TMSCN (1.8eq) and A1C13 (O.O l eq) in dry DCM was stirred for lh under Ar at 0 C, then TosCl (1.72 eq) was added. The resulting mixture was stirred for 48h under Ar at rt. The solvent was removed under reduced pressure, then the residue was treated with EtOH and the reaction was filtered give a solid. The solid was added to dry THF, then DBU (1.2eq) was added to the mixture. The mixture was stirred for 2 h under Ar at rt, then aqueous NH4CI was added and the mixture was extracted with EtOAc, the organic layer was dried with Na2S04, concentrated and the residue was purified by silica column chromatography to give pyridazine-3-carbonitrile (compound 2-Im-8).
The synthetic route of 289-80-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; GALEMMO, Robert, A., Jr.; ARTIS, Dean, Richard; YE, Xiaocong, Michael; AUBELE, Danielle, L.; TRUONG, Anh, P.; BOWERS, Simeon; HOM, Roy, K.; ZHU, Yong-Liang; NEITZ, R., Jeffrey; SEALY, Jennifer; ADLER, Marc; BEROZA, Paul; ANDERSON, John, P.; WO2011/79114; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem