With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.372118-01-9,Methyl 4,6-dichloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.,372118-01-9
Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (414 mg, 2.00 mmol)And 5- (methylthio) pyridin-2-amine (280 mg, 2 mmol) were dissolved in ethanol (3 mL), heated at 120 C in a microwave reactor, and stirred for 3 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 50/1 to 1/1),The target product 6-chloro-4-((5- (methylthio) pyridin-2-yl) amino) pyridazine-3-carboxylic acid methyl ester 14a (120 mg, yellow oil) was obtained,Yield: 19%.
The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
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