5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5096-73-1
2-[6-((1R,2R)-1-Benzyl-2-ethoxycarbonyl-2-hydroxy-ethylcarbamoyl)-pyridazin-3-yl]-benzoic Acid Ethyl Ester (R1=-OCH2CH3; R41=-CH7CH3) 6-Chloropyridazine-3-carboxylic acid (71 mg, 440 mmol, 1.0 eq.), K2CO3 (185 mg, 1.3 mmol, 3.0 eq.), and 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid ethyl ester (148 mg, 535 mmol, 1.2 eq.) were combined with EtOH (1 mL) and water (0.3 mL). The mixture was stirred, and the reaction vessel was capped, placed under vacuum and purged with nitrogen. SilicaCat DPP-Pd (280 mumol/g loading; 286 mg, 80.2 mmol) was added. The vessel was recapped and microwaved at 100 C. for 20 minutes. The solvent was removed and the product filtered. The pH was adjusted to ~4 with 1N HCl. HATU (136 mg, 356 mmol, 0.8 eq.), DIPEA (233 mL, 3.0 eq.), and (2R,3R)-3-amino-2-hydroxy-4-phenyl-butyric acid ethyl ester (99.5 mg, 446 mmol, 1.0 eq.) were combined in DCM (2 mL) and stirred for 2 hours. AcOH was added and the product was purified by preparative HPLC to yield the title compound as a TFA salt (1.8 mg, 95% purity). MS m/z [M+H]+ calc’d for C26H27N3O6, 478.19. found 478.
The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THERAVANCE, INC.; US2012/309724; (2012); A1;,
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