Electric Literature of 37444-46-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 37444-46-5, Pyridazin-3-ylmethanol, introducing its new discovery.
Orally active cephalosporins. Part 3: Synthesis, structure-activity relationships and oral absorption of novel C-3 heteroarylmethylthio cephalosporins
A series of 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3- (heteroarylmethylthio)cephalosporins was designed, synthesized and evaluated for antibacterial activity and oral absorption in rats. Antibacterial activity was markedly influenced by the structure of the heteroaromatic ring moiety. Oral absorption was influenced by the heteroaromatic ring moiety as well as by the arrangement of heteroatoms. Among these compounds, FK041 (2o), having a 4-pyrazolylmethylthio moiety, showed potent antibacterial activity against both Gram-positive and Gram-negative bacteria including Haemophilus influenzae. Further, it showed higher oral absorption than CFDN.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 37444-46-5. In my other articles, you can also check out more blogs about 37444-46-5
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N349 – PubChem