Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C4H2Cl2N2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 141-30-0
Synthesis and in vitro evaluation of imidazo[1,2- b ]pyridazines as ligands for beta-amyloid plaques
A series of imidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for binding to amyloid plaques in vitro using synthetic aggregates of Abeta1?40. Binding affinities of these compounds were found to range from 11.0 to >1000 nM, depending on the various substitution patterns in the 6-position and 2-position. 2-(4?-Dimethylaminophenyl)-6- (methylthio)imidazo[1,2-b]pyridazine (4) showed high binding affinity (K i = 11.0 nM) and might be useful for the development of novel positron emission tomography radiotracers for imaging Abeta plaques.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1975 – PubChem