Month: February 2023

Reactions of 3-aroylacrylates with 伪-aminoazoles was written by Kolos, N. N.;Kovalenko, L. U.;Borovskoy, V. A.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2011.Recommanded Product: 6-(4-Chlorophenyl)pyridazin-3(2H)-one This article mentions the following:

Dihydro derivatives of pyrazolo[3,4-b]pyridine-, pyrazolo[1,5-a]pyrimidine-, and [1,2,4]triazolo-[1,5-a]pyrimidinecarboxylates have been prepared by cyclocondensation of 尾-aroylacrylates with 5-aminopyrazoles and 3-amino-1,2,4-triazole. Heating dihydro[1,2,4]triazolo[1,5-a]pyrimidine-7-carboxylates with hydrazine hydrate led to recyclization of the pyrimidine ring to form 6-arylpyridazin-3(2H)-ones. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Recommanded Product: 6-(4-Chlorophenyl)pyridazin-3(2H)-one).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Recommanded Product: 6-(4-Chlorophenyl)pyridazin-3(2H)-one

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses was written by Watterson, D. Martin;Haiech, Jacques;Van Eldik, Linda J.. And the article was included in Journal of Molecular Neuroscience in 2002.Product Details of 5469-70-5 This article mentions the following:

The authors used a chem. genomics approach that includes follow up in parallel syntheses to discover a new class of compounds that selectively suppress glial activation. While the mechanism of action remains to be determined, available data and the exptl. approach for discovery indicate that the mechanism includes inhibition of gene regulating protein kinases. Specifically, the increased production of IL-1尾 and iNOS in response to various activating stimuli, including A尾1-42, is suppressed while the production of potentially beneficial responses, such as ApoE production, is not inhibited. The increased production of COX-2 and p38 MAPK activation are also not altered, demonstrating the novel nature of potential therapeutic targets compared to currently available drugs. The chem. scaffold is 3-aminopyridazine (3-AP). This is an attractive scaffold because of its potential for diversification by established, facile chemistries and the prior use of a 3-AP scaffold in other central nervous system targeted therapeutics. Therefore, the potential bioavailability of 3-AP derivatives and the demonstrated cellular selectivity demand that future research address the potential efficacy of selective 3-AP derivatives in animal models of disease. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Product Details of 5469-70-5).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Product Details of 5469-70-5

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Paper-chromatographic techniques for hydrazides and certain metabolites was written by Greulach, Victor A.;Haesloop, John G.. And the article was included in Anal. Chem. in 1961.Quality Control of 1,2-Dihydro-4-methyl-3,6-pyridazinedione This article mentions the following:

A large number of hydrazides were separated by descending chromatography by using either 7:1:2 iso-PrOH:NH₄OH:H₂O or 5:1:4 BuOH:HOAc:H₂O. Alternatively, 2-dimensional separation could be used, developing with each solvent in turn. Spots were visualized by spraying with a freshly prepared 1:1 mixture of 1% FeCl₃ and 1% K₃Fe(CN)₆. Some sugars, including sucrose, glucose, mannose, fructose, arabinose, xylose, and ribose, and some amino acids, including cysteine, asparagine, histidine, proline, valine, tyrosine, and tryptophan, also gave a color with the reagent. In the experiment, the researchers used many compounds, for example, 1,2-Dihydro-4-methyl-3,6-pyridazinedione (cas: 5754-18-7Quality Control of 1,2-Dihydro-4-methyl-3,6-pyridazinedione).

1,2-Dihydro-4-methyl-3,6-pyridazinedione (cas: 5754-18-7) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Quality Control of 1,2-Dihydro-4-methyl-3,6-pyridazinedione

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Electrophotocatalytic C-H Azolation of Arenes was written by Hou, Zhong-Wei;Xu, Hai-Chao. And the article was included in ChemElectroChem in 2021.COA of Formula: C6H5N3 This article mentions the following:

An electrophotocatalytic method was developed for the dehydrogenative cross coupling of arenes with azoles employing a bicatalytic system consisting of acridinium dye and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). The reactions were conducted in a simple undivided cell with visible-light irradiation and requires no external chem. oxidant. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2COA of Formula: C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators was written by Sharma, Lalit Kumar;Yun, Mi Kyung;Subramanian, Chitra;Tangallapally, Rajendra;Jackowski, Suzanne;Rock, Charles O.;White, Stephen W.;Lee, Richard E.. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Recommanded Product: 3,6-Dichloropyridazine This article mentions the following:

Pantothenate kinase (PANK) is the critical regulator of intracellular levels of CoA and has emerged as an attractive target for treating neurol. and metabolic disorders. This report describes the optimization, synthesis, and full structure-activity relationships of a new chem. series of pantothenate competitive PANK inhibitors. Potent drug-like mols. were obtained by optimizing a high throughput screening hit, using lipophilic ligand efficiency (LipE) derived from human PANK3 IC₅₀ values to guide ligand development. X-ray crystal structures of PANK3 with index inhibitors from the optimization were determined to rationalize the emerging structure activity relationships. The anal. revealed a key bidentate hydrogen bonding interaction between pyridazine and R306鈥?as a major contributor to the LipE gain observed in the optimization. A tractable series of PANK3 modulators with nanomolar potency, excellent LipE values, desirable physicochem. properties, and a well-defined structural binding mode was produced from this study. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Recommanded Product: 3,6-Dichloropyridazine).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Recommanded Product: 3,6-Dichloropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

A new alkylation of pyridazines with nitromethane and nitroethane was written by Yanai, Mitsuji;Takeda, Shigeko;Nishikawa, Makoto. And the article was included in Heterocycles in 1976.Category: pyridazine This article mentions the following:

The pyridazinecarboxylate I (R = 4-CO2Et) was alkylated by R1NO2 (R1 = Me, Et) to give II. I (R = 5-CO2Et) was similarly alkylated, whereas I (R = 4-CO2H, 5-CO2H) and 3-hydroxy-4-pyridazinecarboxylic acid were alkylated with decarboxylation. Me2SO was the best solvent and K2CO3 and NEt3 were suitable catalysts. In the experiment, the researchers used many compounds, for example, Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9Category: pyridazine).

Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Reexamination of the application of linear free energy relationships to the azaheterocyclic systems. I. Substituent effects on the basicity of monocyclic azines was written by Tomasik, P.;Zalewski, R.. And the article was included in Chemicke Zvesti in 1977.Safety of 3-Aminopyridazine This article mentions the following:

The basicities of pyridines, pyrimidines, pyridazines, and pyrazines (180 compounds) were correlated with substituent effects by Hammett and Taft equations. Limitations of the LFER are discussed. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Safety of 3-Aminopyridazine).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Safety of 3-Aminopyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions was written by Handa, Sachin;Jin, Bo;Bora, Pranjal P.;Wang, Ye;Zhang, Xiaohua;Gallou, Fabrice;Reilly, John;Lipshutz, Bruce H.. And the article was included in ACS Catalysis in 2019.Related Products of 766-55-2 This article mentions the following:

Nanoparticles derived from FeCl₃ containing the ligand XPhos and only 500 ppm Pd effect Sonogashira couplings in water between rt and 45掳. The entire aqueous reaction medium can be easily recycled using an “in-flask” extraction Several tandem processes in one pot are illustrated, including a sequence involving five steps (10 reactions) in good overall yield. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Related Products of 766-55-2).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Related Products of 766-55-2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Amination of chloro-substituted heteroarenes with adamantane-containing amines was written by Abel, A. S.;Grigorova, O. K.;Averin, A. D.;Maloshitskaya, O. A.;Butov, G. M.;Savelyev, E. N.;Orlinson, B. S.;Novakov, I. A.;Beletskaya, I. P.. And the article was included in Russian Chemical Bulletin in 2016.Recommanded Product: 141-30-0 This article mentions the following:

Amination of 3,6-dichloropyridazine, chloropyrazine, 2,3- and 2,6-dichloropyrazines, 2-chloroquinoxaline, 1-chloro and 1,3-dichloroisoquinolines with various adamantane-containing amines characterized by different steric hindrances at the amino group was studied. The yields of the amination products depended on the structure of starting compounds In the reactions of all the dichloroheteroarenes, selective substitution of only one chlorine atom took place, with the best yields being observed for 2,6-dichloropyrazine. In the reaction of 1,3-dichloroisoquinoline, the chlorine atom at position 1 was selectively substituted in up to 90% yield. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Recommanded Product: 141-30-0).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Recommanded Product: 141-30-0

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function was written by Collibee, Scott E.;Bergnes, Gustave;Chuang, Chihyuan;Ashcraft, Luke;Gardina, Jeffrey;Garard, Marc;Jamison, Chris R.;Lu, Kevin;Lu, Pu-Ping;Muci, Alexander;Romero, Antonio;Valkevich, Ellen;Wang, Wenyue;Warrington, Jeffrey;Yao, Bing;Durham, Nickie;Hartman, James;Marquez, Anna;Hinken, Aaron;Schaletzky, Julia;Xu, Donghong;Hwee, Darren T.;Morgans, David;Malik, Fady I.;Morgan, Bradley P.. And the article was included in Journal of Medicinal Chemistry in 2021.Safety of 3,6-Dichloropyridazine This article mentions the following:

Herein, the discovery of reldesemtiv I, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit, 4-(4-fluorobenzyl)-5-(phenethylamino)-1,2,4-thiadiazole, led to compounds with improved free exposure and in vivo muscle activation potency compared to the first-generation FSTA, tirasemtiv. The compound I demonstrated increased muscle force generation in a phase 1 clin. trial and is currently being evaluated in clin. trials for the treatment of amyotrophic lateral sclerosis. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Safety of 3,6-Dichloropyridazine).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Safety of 3,6-Dichloropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem