Ultrasonicated synthesis of N-benzyl-2,3-substituted morpholines, via the Mitsunobu diol cyclisation was written by Reddy, B. Jayachandra;Reddy, M. C. Somasekhara. And the article was included in E-Journal of Chemistry in 2010.Name: 3-Aminopyridazine This article mentions the following:
A facile five-step synthesis of N-benzyl-2,3-substituted morpholines was performed. The key steps were microwave-assisted Friedel-Crafts acylation and diol cyclization carried out via an ultra sonication of Mitsunobu reaction using diethylazodicarboxylate, TPP in THF for 1 h. The morpholine products were generated as diastereomers which was separated by the column chromatog. in yields. The structure of compounds was characterized by the spectral data. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Name: 3-Aminopyridazine).
3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Name: 3-Aminopyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem