Reaction of 6-aryl-4,5-dihydro-3-(2H)-pyridazinones with molecular bromine. Reaction features and mechanism was written by Ovchinnikov, K. L.;Cherkalin, M. S.;Kurmanov, A. M.;Sadovnikova, Ya. V.;Kolobov, A. V.;Kofanov, E. R.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2011.Category: pyridazine This article mentions the following:
Dehydration of 6-aryl-4,5-dihydropyridazin-3(2H)-ones by Br2 was studied. The reaction was shown to proceed through the formation of the enamine form of the substrate. The reaction mechanism was proposed. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Category: pyridazine).
6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Category: pyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem