Copper-Catalyzed Bisannulations of Malonate-Tethered O-Acyl Oximes with Pyridine, Pyrazine, Pyridazine, and Quinoline Derivatives for the Construction of Dihydroindolizine-Fused Pyrrolidinones and Analogues was written by Miao, Chun-Bao;Guan, Hong-Rong;Tang, YiHan;Wang, Kun;Ren, Wen-Long;Lyu, Xinyu;Yao, ChangSheng;Yang, Hai-Tao. And the article was included in Organic Letters in 2021.Formula: C4H2Cl2N2 This article mentions the following:
A copper-catalyzed bisannulation reaction of malonate-tethered O-acyl oximes RC(=NOAc)CH2CH(CO2Et)2 (R = Me, Ph, 2-furyl, etc.) with pyridine, pyrazine, pyridazine, and quinoline derivatives, e.g., 2-quinolineacetic acid, Et ester has been developed for the concise synthesis of structurally novel dihydroindolizine-fused pyrrolidinones, e.g., I and their analogs. The present reaction shows excellent regioselectivity and stereoselectivity. Theor. calculations reveal that the coordination effect of the carbonyl group in the nucleophilic substrate determines the excellent regioselectivity. Further functionalization of the generated dihydroindolizine-fused pyrrolidinone could be easily realized through substitution, Michael addition, selective aminolysis, and hydrolysis reactions. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Formula: C4H2Cl2N2).
3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Formula: C4H2Cl2N2
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem