Unprotected Amino Acids as Stable Radical Precursors for Heterocycle C-H Functionalization was written by Mai, Duy N.;Baxter, Ryan D.. And the article was included in Organic Letters in 2016.Recommanded Product: 141-30-0 This article mentions the following:
An efficient and general method for the C-H alkylation of heteroarenes using unprotected amino acids as stable alkyl radical precursors is reported. This one-pot procedure is performed open to air under aqueous conditions and is effective for several natural and unnatural amino acids. Heterocycles of varying structure are suitably functionalized, and reactivity trends reflect the nucleophilic character of the radical species generated. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Recommanded Product: 141-30-0).
3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Recommanded Product: 141-30-0
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem