Llona-Minguez, Sabin et al. published their research in Journal of Medicinal Chemistry in 2017 | CAS: 141-30-0

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Recommanded Product: 3,6-Dichloropyridazine

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors was written by Llona-Minguez, Sabin;Hoeglund, Andreas;Ghassemian, Artin;Desroses, Matthieu;Calderon-Montano, Jose Manuel;Burgos Moron, Estefania;Valerie, Nicholas C. K.;Wiita, Elisee;Almloef, Ingrid;Koolmeister, Tobias;Mateus, Andre;Cazares-Koerner, Cindy;Sanjiv, Kumar;Homan, Evert;Loseva, Olga;Baranczewski, Pawel;Darabi, Masoud;Mehdizadeh, Amir;Fayezi, Shabnam;Jemth, Ann-Sofie;Warpman Berglund, Ulrika;Sigmundsson, Kristmundur;Lundbaeck, Thomas;Jenmalm Jensen, Annika;Artursson, Per;Scobie, Martin;Helleday, Thomas. And the article was included in Journal of Medicinal Chemistry in 2017.Recommanded Product: 3,6-Dichloropyridazine This article mentions the following:

The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool “housekeeping” enzyme responsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has been associated with cancer progression and cancer cell stemness. We have identified a series of piperazin-1-ylpyridazines as a new class of potent dCTPase inhibitors. Lead compounds increase dCTPase thermal and protease stability, display outstanding selectivity over related enzymes and synergize with a cytidine analog against leukemic cells. This new class of dCTPase inhibitors lays the first stone toward the development of drug-like probes for the dCTPase enzyme. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Recommanded Product: 3,6-Dichloropyridazine).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Recommanded Product: 3,6-Dichloropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem