Practical synthesis of a peptide deformylase (PDF) inhibitor was written by Liu, Yugang;Prashad, Mahavir;Ciszewski, Lech;Vargas, Kevin;Repic, Oljan;Blacklock, Thomas J.. And the article was included in Organic Process Research & Development in 2008.Electric Literature of C4H5N3 This article mentions the following:
A practical chromatog.-free synthesis of an N-formylated hydroxylamine peptide deformylase inhibitor LCD320 (I) is described. A diastereoselective Michael reaction of (4S)-3-[2-(cyclobutylmethyl)-1-oxo-2-propenyl]-4-(phenylmethyl)-2-oxazolidinone with O-benzyl hydroxylamine was used to establish the key stereogenic center. We found that traces of residual Li+ from a previous step had a great impact on the diastereoselectivity of this reaction. A very efficient amidation coupling reaction of proline derivative (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylic acid 1,1-dimethylethyl ester with weakly nucleophilic 3-pyridazinamine using methanesulfonyl chloride in the presence of 1-methylimidazole in DMF was also developed that proceeded without racemization. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Electric Literature of C4H5N3).
3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Electric Literature of C4H5N3
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem