Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors was written by Liscio, Paride;Carotti, Andrea;Asciutti, Stefania;Karlberg, Tobias;Bellocchi, Daniele;Llacuna, Laura;Macchiarulo, Antonio;Aaronson, Stuart A.;Schuler, Herwig;Pellicciari, Roberto;Camaioni, Emidio. And the article was included in Journal of Medicinal Chemistry in 2014.Electric Literature of C4H3Cl2N3 This article mentions the following:
Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]pyridazines has been synthesized and characterized biol. Structure-based optimization of the starting hit compound N-(4-chlorophenyl)-6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-amine (NNL) prompted the authors to the discovery of 4-(2-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-ylamino)ethyl)phenol (I), a low nanomolar selective TNKSs inhibitor working as NAD isostere as ascertained by crystallog. anal. Preliminary biol. data candidate this new class of derivatives as a powerful pharmacol. tools in the unraveling of TNKS implications in physiopathol. conditions. In the experiment, the researchers used many compounds, for example, 4-Amino-3,6-dichloropyridazine (cas: 823-58-5Electric Literature of C4H3Cl2N3).
4-Amino-3,6-dichloropyridazine (cas: 823-58-5) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Electric Literature of C4H3Cl2N3
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem