Li, Zhanhui et al. published their research in European Journal of Medicinal Chemistry in 2022 | CAS: 887625-09-4

2-Amino-6-chloroimidazo[1,2-b]pyridazine (cas: 887625-09-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Related Products of 887625-09-4

Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity was written by Li, Zhanhui;Hao, Yongjin;Yang, Chengkui;Yang, Qing;Wu, Shuwei;Ma, Haikuo;Tian, Sheng;Lu, Haohao;Wang, Jingrui;Yang, Tao;He, Sudan;Zhang, Xiaohu. And the article was included in European Journal of Medicinal Chemistry in 2022.Related Products of 887625-09-4 This article mentions the following:

RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, we report a series of potent RIPK1 inhibitors, represented by compound 70. Compound 70 efficiently blocks necroptosis induced by TNFα in both human and mouse cells (EC50 = 17-30 nM). Biophys. assay demonstrates that compound 70 potently binds to RIPK1 (Kd = 9.2 nM), but not RIPK3 (Kd > 10,000 nM). Importantly, compound 70 exhibits greatly improved metabolic stability in human and rat liver microsomes compared to compound 6 (PK68), a RIPK1 inhibitor reported in our previous work. In addition, compound 70 displays high permeability in Caco-2 cells and excellent in vitro safety profiles in hERG and CYP assays. Moreover, pre-treatment of 70 significantly ameliorates hypothermia and lethal shock in SIRS mice model. Lastly, compound 70 possesses favorable pharmacokinetic parameters with moderate clearance and good oral bioavailability in SD rat. Taken together, our work supports 70 as a potent RIPK1 inhibitor and highlights its potential as a prototypical lead for further development in necroptosis-associated inflammatory disorders. In the experiment, the researchers used many compounds, for example, 2-Amino-6-chloroimidazo[1,2-b]pyridazine (cas: 887625-09-4Related Products of 887625-09-4).

2-Amino-6-chloroimidazo[1,2-b]pyridazine (cas: 887625-09-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Related Products of 887625-09-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem