Synthesis of polyfunctional fluoro-quinoline and fluoro-pyridopyrimidinone derivatives was written by Heeran, Darren;Murray, Ben J.;Qiu, Sili;Martin, Sophie J.;Skelton, Robert M.;Dodds, Kiera R.;Yufit, Dmitry S.;Sandford, Graham. And the article was included in Journal of Fluorine Chemistry in 2021.Electric Literature of C4H5N3 This article mentions the following:
2-Fluoromalonic acid is a useful building block for the synthesis of selectively fluorinated heterocycles. In the presence of phosphoryl chloride, chlorinated fluoroquinolines and fluoro-pyridopyrimidinones were prepared in a single step by an efficient tandem chlorination-cyclisation process. Functionalisation by Suzuki cross-coupling or SNAr processes allowed for the rapid construction of a small library of 30 novel polysubstituted selectively fluorinated quinoline and pyridopyrimidinone derivatives in high yields and bearing a diverse range of substituents. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Electric Literature of C4H5N3).
3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Electric Literature of C4H5N3
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem