A new alkylation of pyridazines with nitromethane and nitroethane was written by Yanai, Mitsuji;Takeda, Shigeko;Nishikawa, Makoto. And the article was included in Heterocycles in 1976.Category: pyridazine This article mentions the following:
The pyridazinecarboxylate I (R = 4-CO2Et) was alkylated by R1NO2 (R1 = Me, Et) to give II. I (R = 5-CO2Et) was similarly alkylated, whereas I (R = 4-CO2H, 5-CO2H) and 3-hydroxy-4-pyridazinecarboxylic acid were alkylated with decarboxylation. Me2SO was the best solvent and K2CO3 and NEt3 were suitable catalysts. In the experiment, the researchers used many compounds, for example, Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9Category: pyridazine).
Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Category: pyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem