6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Computed Properties of C10H7ClN2O
Synthesis of glucosides. XXI. Synthesis of 2-N-(尾-D-glucopyranos-1-yl)-6-(4-halophenyl)-3-pyridazinones was written by Xin, Bing-Wei;Sun, Chang-Jun;Qu, Li-Qiang;Cao, Xiao-Ran. And the article was included in Yingyong Huaxue in 2003.Computed Properties of C10H7ClN2O This article mentions the following:
Four pyridazinone glucosides I (X = F, Cl, Br, I) were synthesized by reaction of 2,3,4,6-tetra-O-acetyl-1-bromo-1-deoxy-伪-D-glucopyranose with 6-(4-halophenyl)-3(2H)-pyridazinones under phase transfer catalysis conditions, followed by treatment with dry ammonia at 0 鈭?-5掳C. Their structures were characterized by IR, 1H NMR, 13C NMR and elemental anal. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Computed Properties of C10H7ClN2O).
6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Computed Properties of C10H7ClN2O
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem