Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses was written by Watterson, D. Martin;Haiech, Jacques;Van Eldik, Linda J.. And the article was included in Journal of Molecular Neuroscience in 2002.Product Details of 5469-70-5 This article mentions the following:
The authors used a chem. genomics approach that includes follow up in parallel syntheses to discover a new class of compounds that selectively suppress glial activation. While the mechanism of action remains to be determined, available data and the exptl. approach for discovery indicate that the mechanism includes inhibition of gene regulating protein kinases. Specifically, the increased production of IL-1尾 and iNOS in response to various activating stimuli, including A尾1-42, is suppressed while the production of potentially beneficial responses, such as ApoE production, is not inhibited. The increased production of COX-2 and p38 MAPK activation are also not altered, demonstrating the novel nature of potential therapeutic targets compared to currently available drugs. The chem. scaffold is 3-aminopyridazine (3-AP). This is an attractive scaffold because of its potential for diversification by established, facile chemistries and the prior use of a 3-AP scaffold in other central nervous system targeted therapeutics. Therefore, the potential bioavailability of 3-AP derivatives and the demonstrated cellular selectivity demand that future research address the potential efficacy of selective 3-AP derivatives in animal models of disease. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Product Details of 5469-70-5).
3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Product Details of 5469-70-5
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem