The effect of solvent on the synthesis of pyridazinones and some reactions of the new compounds was written by Sayed, Galal Hosni;Radwan, Azza;Hamed, Ashraf Ahmed;Boraie, Waleed El Sayed. And the article was included in Bulletin of the Chemical Society of Japan in 1993.Application of 2166-13-4 This article mentions the following:
The reaction of 4-aryl-4-oxo-2-(5-oxo-1,3-diphenyl-2-pyrazolin-4-yl)butanoic acids with hydrazine hydrate in ethanol afforded (oxopyrazolinyl)pyridazinones I (R = p-ClC6H4, p-tolyl); in 1-butanol pyrazolo[3,4-c]pyridazino[4,3-e]pyridazine derivative II was obtained, while in acetic acid the 6-aryl-3(2H)-pyridazinone was the product. A probable mechanism has been proposed. The behavior of I toward di-Me sulfate, di-Et sulfate, Et bromoacetate, p-anisaldehyde, phosphoryl chloride and phosphorus pentasulfide has been studied. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Application of 2166-13-4).
6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Application of 2166-13-4
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem