Benzohydrazide incorporated imidazo[1,2-b]pyridazine: synthesis, characterization and in vitro anti-tubercular activity was written by Paidi, K. R.;Tatipamula, V. B.;Kolli, M. K.;Pedakotla, V. T.. And the article was included in International Journal of Chemical Sciences in 2017.Application In Synthesis of 3,6-Dichloropyridazine This article mentions the following:
A novel series of imidazo[1,2-b]pyridazine comprising benzohydrazide derivatives I (R = 4-OMe, 3-NO2, 4-Cl, etc.) have been synthesized, characterized by using spectral data and screened for anti-tuberculosis activity. The anti-tubercular activity of the synthesized compounds I was determined by microplate alamar blue assay and the outcomes were screened in vitro against Mycobacterium tuberculosis H37Rv strain. All synthesized compounds exhibited good to potent anti-tubercular activity when compared with the standard first line anti-tuberculosis drugs (ciprofloxacin, pyrazinamide and streptomycin). Some of the tested compounds exhibited highest inhibitory activity at 1.6 μg/mL minimal inhibitory concentration In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Application In Synthesis of 3,6-Dichloropyridazine).
3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Application In Synthesis of 3,6-Dichloropyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem