Microwave assisted synthesis, characterization and pharmacological evaluation of pyridazinone derivatives was written by Jha, K. K.;Kumar, Y.;Shaharyar, Mohd.;Sharma, Gajraj. And the article was included in Asian Journal of Chemistry in 2009.Formula: C10H7ClN2O This article mentions the following:
Two series of compounds I (R = H, Me, Cl etc.) and II were synthesized by microwave assisted methods. These compounds were evaluated for their hypotensive and anticonvulsant activities. They showed the hypotensive activity ranging from 17.8 to 27.4% while standard drug minoxidil showed 27% reduction in blood pressure. All these compounds showed significant anticonvulsant activity when compared with phenytoin. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Formula: C10H7ClN2O).
6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Formula: C10H7ClN2O
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem