7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4- triazol-3-ylmethoxy)-3-(2-fluorophenyl)- 1,2,4-triazolo[4,3-b]pyridazine: A Functionally Selective 纬-Aminobutyric AcidA (GABAA) 伪2/伪3-Subtype Selective Agonist That Exhibits Potent Anxiolytic Activity but Is Not Sedating in Animal Models was written by Carling, Robert W.;Madin, Andrew;Guiblin, Alec;Russell, Michael G. N.;Moore, Kevin W.;Mitchinson, Andrew;Sohal, Bindi;Pike, Andrew;Cook, Susan M.;Ragan, Ian C.;McKernan, Ruth M.;Quirk, Kathleen;Ferris, Pushpinder;Marshall, George;Thompson, Sally Ann;Wafford, Keith A.;Dawson, Gerard R.;Atack, John R.;Harrison, Timothy;Castro, Jose L.;Street, Leslie J.. And the article was included in Journal of Medicinal Chemistry in 2005.Safety of 4-tert-Butyl-3,6-dichloropyridazine This article mentions the following:
There is increasing evidence that compounds with selectivity for 纬-aminobutyric acidA (GABAA) 伪2- and/or 伪3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect profile. Herein we describe a novel series of GABAA 伪2/伪3 subtype-selective agonists leading to the identification of the development candidate 17, a nonsedating anxiolytic in preclin. animal assays. In the experiment, the researchers used many compounds, for example, 4-tert-Butyl-3,6-dichloropyridazine (cas: 22808-29-3Safety of 4-tert-Butyl-3,6-dichloropyridazine).
4-tert-Butyl-3,6-dichloropyridazine (cas: 22808-29-3) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Safety of 4-tert-Butyl-3,6-dichloropyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem