Ionization constants of heterocyclic substances. II. Hydroxy-derivatives of nitrogenous six-membered ring-compounds was written by Albert, Adrien;Phillips, J. N.. And the article was included in Journal of the Chemical Society in 1956.HPLC of Formula: 20733-10-2 This article mentions the following:
Acidic and basic ionization constants were determined potentiometrically and in some cases spectrometrically for 87 hydroxy (and related) derivatives of pyridine, quinoline, isoquinoline, acridine, phenanthridine, pyridazine, pyrimidine, pyrazine, cinnoline, phthalazine, quinazoline, quinoxaline, phenazine, triazine, 1,4,5-triazanaphthalene, and 1,4,6-triazanaphthalene. The tautomeric equilibrium between enol and amide in 伪 and 纬-hydroxy derivatives greatly favor the amide form. The preparation of 2-methoxypyrazine, b29 60-1掳, and 3-hydroxypyridine methochloride were described. A m.p. of 57掳 was reported for 2-methyl-1-isoquinolone. In the experiment, the researchers used many compounds, for example, 4-Hydroxypyridazine (cas: 20733-10-2HPLC of Formula: 20733-10-2).
4-Hydroxypyridazine (cas: 20733-10-2) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.HPLC of Formula: 20733-10-2
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem