Amination of chloro-substituted heteroarenes with adamantane-containing amines was written by Abel, A. S.;Grigorova, O. K.;Averin, A. D.;Maloshitskaya, O. A.;Butov, G. M.;Savelyev, E. N.;Orlinson, B. S.;Novakov, I. A.;Beletskaya, I. P.. And the article was included in Russian Chemical Bulletin in 2016.Recommanded Product: 141-30-0 This article mentions the following:
Amination of 3,6-dichloropyridazine, chloropyrazine, 2,3- and 2,6-dichloropyrazines, 2-chloroquinoxaline, 1-chloro and 1,3-dichloroisoquinolines with various adamantane-containing amines characterized by different steric hindrances at the amino group was studied. The yields of the amination products depended on the structure of starting compounds In the reactions of all the dichloroheteroarenes, selective substitution of only one chlorine atom took place, with the best yields being observed for 2,6-dichloropyrazine. In the reaction of 1,3-dichloroisoquinoline, the chlorine atom at position 1 was selectively substituted in up to 90% yield. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Recommanded Product: 141-30-0).
3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Recommanded Product: 141-30-0
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem