Month: December 2022

Kinetics of reactions in heterocycles. XIV. Reactions of 2- and 4-amino-, -methylamino-, and -dimethylaminopyridine methiodides and 2-methylthiopyrimidine methiodide with hydroxide ions in water was written by Barlin, Gordon B.;Benbow, John A.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1975.Name: 3-Methoxypyridazine This article mentions the following:

The kinetics of the title reactions were studied. The reactions were second order and resulted in the formation of quant. yields of N-methylpyridones. At 20°C 2-dimethylaminopyridine methiodide reacted 8.5 × 103 times faster than the 4-NMe2 analog and these compounds were 2.3 × 10-4 and 3.1 × 10-6 resp., times less reactive than the corresponding 2- and 4-chloropyridine methiodides. 2-Methylthiopyridine methiodide with NaOH gave 1-methylpyrimidin-2-one by a step process. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Name: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Name: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Tautomerism of N-heterocycles. II. 3-Hydroxypyridazin-6-one and 3-mercaptopyridazine-6-thione was written by Barlin, Gordon B.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1974.Synthetic Route of C5H6N2O This article mentions the following:

The ionization constants and uv of 3,6-dimercaptopyridazine and its N-Me and S-Me derivatives indicated that the parent compound existed as 3-mercaptopyridazine-6-thione in aqueous solution; 3,6-dihydroxypyridazine, its N,N-di-Me derivative, and 3-hydroxypyridazine behaved abnormally on protonation, owing to the existence of 2 overlapping ionization constants In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Synthetic Route of C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Synthetic Route of C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Mild and Highly Selective Palladium-Catalyzed Monoarylation of Ammonia Enabled by the Use of Bulky Biarylphosphine Ligands and Palladacycle Precatalysts was written by Cheung, Chi Wai;Surry, David S.;Buchwald, Stephen L.. And the article was included in Organic Letters in 2013.SDS of cas: 13493-79-3 This article mentions the following:

A method for the Pd-catalyzed arylation of ammonia with a wide range of aryl and heteroaryl halides, including challenging five-membered heterocyclic substrates, is described. Excellent selectivity for monoarylation of ammonia to primary arylamines was achieved under mild conditions or at rt by the use of bulky biarylphosphine ligands as well as their corresponding aminobiphenyl palladacycle precatalysts. As this process requires neither the use of a glove box nor high pressures of ammonia, it should be widely applicable. In the experiment, the researchers used many compounds, for example, 6-Chloroimidazo[1,2-b]pyridazine hydrochloride (cas: 13493-79-3SDS of cas: 13493-79-3).

6-Chloroimidazo[1,2-b]pyridazine hydrochloride (cas: 13493-79-3) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.SDS of cas: 13493-79-3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis of pyridazine derivatives. II. The reactivity of chlorine atom in 3- or 6-position of chloropyridazine 1-oxide was written by Sako, Shigeru. And the article was included in Chemical & Pharmaceutical Bulletin in 1963.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

The 6-NH₂ derivative of pyridazine 1-oxide (I) diazotized in HCl, followed by addition of powd. Cu, yielded 61% 6-Cl derivative (II) of I, m. 157-8°. II and its 3-Cl isomer (III) sep. kept 1 hr. at 30° with MeONa in MeOH yielded, resp., 84% 6-MeO derivative (IV) of I, m. 126-7°, and 77% 3-MeO derivative of I, m. 79-80°. Similar treatment of 3-chloropyridazine (V) yielded only 33% 3-methoxypyridazine even after 1 hr. heating (picrate m. 109-11°). Heating II and III 1 hr. in a sealed tube on a steam bath with 70% EtNH₂ in EtOH yielded, resp., 79% 6-EtNH derivative (VI) of I, m. 113-14°, and 70% 3-EtNH derivative (VII) of I, m. 79-80° (picrate m. 131-2°), whereas similar treatment of V gave 97% starting material. However, heating V 3 hrs. at 120-30° with EtNH₂ in a sealed tube yielded 40% 3-ethylaminopyridazine (VIII), m. 93-4° (picrate m. 157-8°), formed also in confirmation of its structure (750% yield) by catalytic reduction (Pd-C) of 3-ethylamino-6-chloropyridazine. II and III yielded, resp., 4% VI and 3.5% VII when heated with EtNH₂ in a sealed tube 5 hrs. at 28°. Oxidation of VIII with H₂O₂ in AcOH yielded 20% VI. Hydrolysis of 301.6 mg. IV by heating 1 hr. on a steam bath with 5% NaOH yielded 83.2 mg. 2-hydroxy-3(2H)-pyridazinone, m. 167-8°, identified by both infrared and ultraviolet absorption spectra. These results showed almost the same reactivity for the Cl atom in the 3- and 6-positions of I, contrary to the case of the 3,6-Cl₂ derivative of I. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Amination of 4-nitropyridazine 1-oxides by liquid ammonia-potassium permanganate was written by Tondys, Hanna;Van der Plas, Henk C.. And the article was included in Journal of Heterocyclic Chemistry in 1986.COA of Formula: C5H6N2O This article mentions the following:

Treatment of 4-nitropyridazine 1-oxide, 3-methoxy-6-chloro-4-nitropyridazine 1-oxide or 3,6-dimethoxy-4-nitropyridazine 1-oxide with a solution of KMnO₄ in NH₃(l) gives in reasonable-to-good yields the corresponding 5-amino-4-nitropyridazine 1-oxides (75%, 54%, and 62%, resp.). 3,6-Dimethoxypyridazine and 3-methoxypyridazine are converted into the corresponding 4-aminopyridazines I [R = R¹ = MeO; R = H, R¹ = MeO (II)] on treatment with KNH₂/NH₂(l)/KMnO₄ (yield 50 and 22% resp.). In the last-mentioned reaction besides II 3,3′-dimethoxy 4,4′-bipyridazine (23%) was obtained. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4COA of Formula: C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.COA of Formula: C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Electron impact studies. XVIII. Mass spectra of pyridazines, phthalazines, and related compounds was written by Bowie, John H.;Cooks, R. Graham;Donaghue, P. F.;Halleday, J. A.;Rodda, Harold J.. And the article was included in Australian Journal of Chemistry in 1967.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

The mass spectra of substituted pyridazines, phthalazines, and related compounds are reported and discussed. Mol. ions are a prominent feature of all the spectra, and fragmentation modes may be usefully correlated with both the type of heterocycle and its substitution pattern. Fragmentation patterns were substantiated by extensive high resolution studies and appropriate metastable ions. 31 references. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The oxidation of s-triazolo[4,3-b]pyridazines with selenium dioxide was written by Iwao, Masatomo;Kuraishi, Tsukasa. And the article was included in Journal of Heterocyclic Chemistry in 1976.COA of Formula: C5H3ClN4O This article mentions the following:

The s-triazolo[4,3-b]pyridazines I (R = Me, MeO, Cl, H, R1 = H; R = Cl, R1 = AcNH) were oxidized to the s-triazolo[4,3-b]pyridazin-3-ones II with SeO2 in PhNO2 at 160-165° for 1-2 hr in 30-40% yields. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7COA of Formula: C5H3ClN4O).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.COA of Formula: C5H3ClN4O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Halogen-exchange fluorination of aromatic halides with HF or HF-base was written by Fukuhara, Tsuyoshi;Yondea, Norihiko. And the article was included in Chemistry Letters in 1993.Product Details of 33097-39-1 This article mentions the following:

Heteroaromatic halides such as 2-chloropyrimidines and 2-chloropyridines, and 2,4-dinitrochlorobenzene underwent halogen-exchange fluorination with the treatment of HF or HF-base solutions to afford the corresponding fluorides in good yields. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Product Details of 33097-39-1).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Product Details of 33097-39-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The tautomerism of N-heteroaromatic hydroxy compounds. I. Infrared spectra was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1957.Application of 19064-65-4 This article mentions the following:

The IR spectra of 37 N-heterocyclic hydroxy compounds have been measured in the O-H, N-H, and double-bond stretching-vibration regions by use of a Perkin-Elmer model 12C spectrometer with a LiF or NaCl prism. The compounds were examined at concentrations of 10^-2 to 10^-3M in cells of 5 cm. (CCl₄) or 1 cm. (CHCl₃) thickness in the O-H and N-H regions, and 1 mm. in the double-bond region, and as solids included in pressed KBr disks. The compounds with a OH group α or γ to a ring-N atom absorb in the N-H and C:O stretching vibration regions both in the solid state and in CHCl₃ solution, and so possess principally amide structures under these conditions. The remaining compounds have mainly enolic structures in solution, showing absorption due to a free or an intramolecularly H-bonded O-H group. The IR evidence for the zwitterionic structure of the latter group of compounds in the solid state is discussed. The compounds which tautomerize to an amide with a quasi ο-quinonoid structure show an N-H stretching vibration absorption in the range 3360-3420 cm.^-1, while their quasi p-quinonoid isomers absorb in the range 3415-45 cm.^-1, and their analogs with 5-membered rings in the range 3440-85 cm.^-1 The position of the C:O band of such compounds depends upon the structural type and the number of N atoms in the ring carrying the potentially tautomeric OH group. For nuclei similarly substituted, the C:O band of the quasiο-quinonoid amides lies at a higher frequency than that of the quasi p-quinonoid isomers. The structures of some dihydroxy and polyaza compounds are elucidated by means of these correlations. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Application of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Application of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Electronic spectra of N-heteroaromatic systems. III. π → π transitions of the monocyclic hydroxyazines was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1959.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

The ultraviolet absorption spectra of the enolic, cationic, anionic, and zwitterionic forms of the monocyclic hydroxyazines have been measured in aqueous solution, and the spectra of the enols and zwitterions, fixed as the O- and the N-Me derivatives, resp., have been obtained in nonpolar solvents. The first absorption band in the spectra of the different charged forms of a given compound lies at wave lengths in the sequence, zwitterion > anion > cation > enol, and the spectrum of the zwitterion shifts considerably towards the red region on changing from aqueous to nonpolar solvents. The solvent effect is inconsistent with the valence-bond theory of the spectra, and a mol.-orbital theory is developed to account for the solvent shifts and the spectral differences between the compounds studied and their various charged forms. The electronic absorption spectra of the 4 forms and the oscillator strength of the π → π absorption band of longest wave length in the spectra of the enolic and zwitterionic forms are given for 2-hydroxy-, 2-methoxy-, 3-hydroxy-, 3-methoxy-, 4-hydroxy-, and 4-methoxypyridine, 1-methyl-2- and 1-methyl-4-pyridone, 3-hydroxypyridine 1-methochloride, 2-hydroxy- and 2-methoxypyrazine, 1-methyl-2-pyrazone, 3-hydroxy-, 3-methoxy-, 4-hydroxy-, and 4-methoxypyridazine, 2-hydroxy-, 2-methoxy-, 4-hydroxy-, 4-methoxy-, and 5-hydroxypyrimidine, 1- and 3-methyl-4-pyrimidone, in various solvents, at different pH values. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem