Month: December 2022

Photolysis of pyridazin-3-one 1-imides: ring contraction into 3-pyrrolin-2-one derivatives was written by Kurita, Jyoji;Takayama, Kazuko;Tsuchiya, Takashi. And the article was included in Chemical & Pharmaceutical Bulletin in 1985.Computed Properties of C5H6N2O This article mentions the following:

Irradiation of pyridazin-3-one 1-ethoxycarbonylimide [I (R = H)] resulted in ring contraction to give the azamaleimide (II), whereas the 6-Me derivative [I (R = Me)], upon irradiation, afforded the 3-pyrrolin-2-one (III). On the other hand, the photolysis of 2-methylpyridazin-3-one 1-imides [IV (R’ = H, Me)] gave both azamaleimides (V; same R’) and 3-pyrrolin-2-ones (VI; same R’). The mechanism of this photoinduced ring contraction reaction is discussed. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Computed Properties of C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Computed Properties of C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Proton NMR studies of protonation in pyridazin-3(2H)-one and 6-hydroxypyridazin-3(2H)-one was written by Barlin, Gordon B.;Fenn, M. David. And the article was included in Australian Journal of Chemistry in 1979.Quality Control of 3-Methoxypyridazine This article mentions the following:

A ¹H NMR study of protonation in pyridazin-3-ol and pyridazine-3,6-diol revealed that the processes are not simple and suggests that a mobile tautomeric equilibrium may be involved. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Quality Control of 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Quality Control of 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Studies on pyridazine derivatives. IX. Note on the ethoxycarbonylation of pyridazinylhydrazones was written by Matyus, P.;Szilagyi, G.;Kasztreiner, E.;Soti, M.;Sohar, P.. And the article was included in Acta Chimica Academiae Scientiarum Hungaricae in 1982.Application of 33050-32-7 This article mentions the following:

Triazolopyridazine derivative I and pyridazine derivative II were prepared, under different conditions, from the pyridazinylhydrazone III and EtO₂COCO₂Et. The reaction of III with EtO₂COCO₂Et at -10° gave I. A mixture of III and EtO₂COCO₂Et in CH₂Cl₂ was refluxed to give II. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Application of 33050-32-7).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Application of 33050-32-7

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis of 6H-1,2,4-triazino-1,2,4-triazolopyridazines. Studies in the field of pyridazine compounds. 22 was written by Kosary, Judit;Jerkovich, Gyula;Polos, Katalin;Kasztreiner, Endre. And the article was included in Magyar Kemiai Folyoirat in 1986.HPLC of Formula: 33050-32-7 This article mentions the following:

The novel ring system 6H-1,2,4-triazino[4,3-b]-1,2,4-triazolo[3,4-f]pyridazine I (R = H, Ph) was prepared either by ring closure of triazolopyridazinylhydrazine derivatives II in polyphosphoric acid or of a hydrazine derived from pyridazino-1,2,4-triazine under the action of tri-Et orthoformate. The first representative of another new ring system 6H-1,2,4-triazino[4,3-b]-1,2,4-triazolo[3,4-f]pyridazine III was prepared by heating triazolopyridazinylhydrazone derivative IV in polyphosphoric acid. I (R = H) and III showed a pos. inotropic effect. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7HPLC of Formula: 33050-32-7).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.HPLC of Formula: 33050-32-7

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Model Studies toward the Total Synthesis of Thebaine by an Intramolecular Cycloaddition Strategy was written by Koukal, Petr;Hajicek, Josef;Gupta, Setu;Hudlicky, Tomas. And the article was included in ChemistrySelect in 2017.Related Products of 19064-65-4 This article mentions the following:

Three model compounds required for an approach to thebaine by intramol. [4+2] cycloaddition were prepared In the first two cases the anticipated cycloaddition products were obtained under thermal conditions. Thermolysis of the third, more advanced model compound, afforded products resulting from rearrangements and/or elimination. A study of analogous intra- and intermol. reactions using benzofuran as dienophile and various electron-poor and electron-rich dienes (pyridazines, pyranones, Danishefsky diene) was undertaken. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Related Products of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Related Products of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors was written by Stevens, Kirk L.;Reno, Michael J.;Alberti, Jennifer B.;Price, Daniel J.;Kane-Carson, Laurie S.;Knick, Victoria B.;Shewchuk, Lisa M.;Hassell, Anne M.;Veal, James M.;Davis, Stephen T.;Griffin, Robert J.;Peel, Michael R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Recommanded Product: 19064-65-4 This article mentions the following:

A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependent kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3β. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Recommanded Product: 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Selective fluorination by halogen exchange of chlorodiazines and chloropyridines promoted by the ‘proton sponge’-triethylamine tris(hydrogen fluoride) system was written by Darabantu, M.;Lequeux, T.;Pommelet, J.-C.;Ple, N.;Turck, A.. And the article was included in Tetrahedron in 2001.Name: 3,6-Difluoropyridazine This article mentions the following:

The ‘proton sponge’-triethylamine tris(hydrogen fluoride) mixtures provide a mild and efficient fluorinating reagent to introduce selectively fluorine atoms by halogen exchange into chlorodiazines and chloronitropyridine series. The PS/Et₃N.3HF mixtures provide an efficient reagent to realize a selective fluorination of various π-deficient chlorinated heterocycles: (benzo)diazines and pyridines. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Name: 3,6-Difluoropyridazine).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Name: 3,6-Difluoropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. XXIII. Synthesis of N-substituted 1,4-dihydropyridazines was written by Kaneko, Chisato;Tsuchiya, Takashi;Igeta, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1974.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

1-Methylpyridazinium salts, derived from pyridazines I to VI, were reduced with NaBH4 to give the corresponding 1-methyl-1,6-dihydropyridazines VII in 40-60% yields. Pyridazines I to VI were reduced with NaBH4 in the presence of MeO2CCl to afford 1-methoxycarbonyl-1,6-dihydropyridazines VIII and their 1,4-isomers IX, in total 35-65% yields, ratio of which depended on the kinds of the substituents. Thus, I gave little of the corresponding IX, while V gave little VIII. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

3-Benzyloxy-6-fluoropyridazine was written by Hu, Fang Zhong;Zhang, Min;Song, Hai Bin;Zou, Xiao Mao;Yang, Hua Zheng. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2005.Name: 3,6-Difluoropyridazine This article mentions the following:

The title mol., C₁₁H₉FN₂O, was synthesized from 3,6-difluoropyridazine, benzyl alc. and NaOH in MeCN under reflux. Crystallog. data are given. The asym. unit contains two independent mols. with nearly identical geometry. In the crystal structure, the mols. are linked by weak intermol. C-H···F H bonds and C-H···π interactions. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Name: 3,6-Difluoropyridazine).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Name: 3,6-Difluoropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Reaction of methoxy-N-heteroaromatics with phenylacetonitrile under basic conditions was written by Yamanaka, Hiroshi;Ohba, Setsuya. And the article was included in Heterocycles in 1990.COA of Formula: C5H6N2O This article mentions the following:

The monomethoxy derivatives (I) of various π-electron deficient N-heteroaromatics reacted with PhCH₂CN in THF in the presence of NaH to give α-phenyl-N-heteroareneacetonitriles in 45-78% yields. Other active methylene compounds, e.g., NCCH₂CO₂Et or NCCH₂CN were less reactive towards (I) under similar conditions. The synthesis of benzoyl-N-heteroaromatics by the air oxidation of α-phenyl-N-heteroareneacetonitriles is also described. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4COA of Formula: C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem